Separate crescent dough into four rectangles; seal perforations. Spread cream cheese over each rectangle to within 1/4" of edges. Top each with ham, leaving 1/4" uncovered on one long side. Place two asparagus spears along the long side with the ham; roll up and press seam to seal.
Cut each roll into seven pieces. Place cut side down 1" apart on greased baking sheets. Combine butter and garlic powder; brush over spirals. Bake at 375° for 10-12 minutes or until golden brown.